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University of Washington School of Medicine, Department of Microbiology     

Mullins Lab Publications

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  • Matthews PC, Prendergast A, Leslie A, Crawford H, Payne R, Rousseau C, Rolland M, Honeyborne I, Carlson J, Kadie C, Brander C, Bishop K, Mlotshwa N, Mullins JD, Coovadia H, Ndung'u T, Walker BD, Heckerman D, Goulder PJ. 2008. Central Role of Reverting Mutations in HLA Associations with HIV Viral Setpoint. Journal of Virology (epub ahead of print) [pubmed | hubmed].
  • Rousseau, C. M., M. G. Daniels, J. M. Carlson, C. Kadie, H. Crawford, A. Prendergast, P. Matthews, R. Payne, M. Rolland, D. N. Raugi, B. S. Maust, G. H. Learn, D. C. Nickle, H. Coovadia, T. Ndung'u, N. Frahm, C. Brander, B. D. Walker, P. J. Goulder, T. Bhattacharya, D. E. Heckerman, B. T. Korber, and J. I. Mullins. 2008. HLA class-I driven evolution of human immunodeficiency virus type 1 subtype C proteome: Immune escape and viral load. Journal of Virology 82: 6434-6446 [pubmed | hubmed].
  • Gottlieb, G. S., L. Heath, D. C. Nickle, K. G. Wong, S. E. Leach, B. Jacobs, S. Gezahegne, A. B. van 't Wout, L. P. Jacobson, J. B. Margolick, and J. I. Mullins. 2008. HIV-1 variation before seroconversion in men who have sex with men: analysis of acute/early HIV infection in the multicenter AIDS cohort study. Journal of Infectious Diseases 197: 1011-1015 [pubmed | hubmed].
  • Liu, Y., M. E, Curlin, K. Diem, H. Zhao, A. K. Ghosh, H. Zhu, A. S. Woodward, J. Maenza, C. E. Stevens, J. Stekler, A. C. Collier, I. Genowati, W. Deng, R. Zioni, L. Corey, T. Zhu, and J. I. Mullins. 2008. Env length and N-linked glycosylation following transmission of human immunodeficiency virus type 1 subtype B viruses. Virology 374: 229-233 [pubmed | hubmed].
  • Chun, T. W., D. C. Nickle, J. S. Justement, J. H. Meyers, G. Roby, C. W. Hallahan, S. Kottilil, S. Moir, J. M. Mican, J. I. Mullins, D. J. Ward, J. A. Kovacs, P. J. Mannon, and A. S. Fauci. 2008. Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy. Journal of Infectious Diseases 197: 714-720 [pubmed | hubmed].
  • Frahm, N., D. C. Nickle, C. H. Linde, D. E. Cohen, R. Zuñiga, A. Lucchetti, T. Roach, B. D. Walker, T. M. Allen, B. T. Korber, J. I. Mullins, and C. Brander. 2008. Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity. AIDS 22: 447-456 [pubmed | hubmed].
  • Ngumbela, K. C., C. L. Day, Z. Mncube, K. Nair, D. Ramduth, C. Thobakgale, E Moodley, S Reddy, C. de Pierres, N. Mkhwanazi, K. Bishop, M. van der Stok, N. Ismail, I. Honeyborne, H. Crawford, D. G. Kavanagh, C. Rousseau, D. Nickle, J. Mullins, D. Heckerman, B. Korber, H. Coovadia, P. Kiepiela, P. J. Goulder, and B. D. Walker. 2008. Targeting of a CD8 T cell Env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure. AIDS Research and Human Retroviruses 24: 72-82 [pubmed | hubmed].
  • Herbeck, J. T., G. S. Gottlieb, X. Li, Z. Hu, R. Detels, J. Phair, C. Rinaldo, L. P. Jacobson, J. B. Margolick, and J. I. Mullins. 2008. Lack of evidence for changing virulence of HIV-1 in North America. PLoS ONE 3: e1525 [pubmed | hubmed].
  • Nickle, D. C., N. Jojic, D. Heckerman, V. Jojic, D. Kirovski, M. Rolland, S. Kosakovsky Pond, and J. I. Mullins. 2008. Comparison of immunogen designs that optimize peptide coverage: reply to Fischer et al. PLoS Computational Biology 4: e25 [pubmed | hubmed].
  • Rolland, M., D. Heckerman, W. Deng, C. M. Rousseau, H. Coovadia, K. Bishop, P. J. R. Goulder, B. D. Walker, C. Brander, and J. I. Mullins. 2008. Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads. PLoS ONE 3: e1424 [pubmed | hubmed].
  • Xu, Y., H. Zhu, C. K. Wilcox, A. van 't Wout, T. Andrus, N. Llewellyn, L. Stamatatos, J. I. Mullins, L. Corey, and T. Zhu. 2008. Blood monocytes harbor HIV type 1 strains with diversified phenotypes including macrophage-specific CCR5 virus. Journal of Infectious Diseases 197: 309-318 [pubmed | hubmed].
  • Cao, J., J. McNevin, M. McSweyn, Y. Liu, J. I. Mullins, and M. J. McElrath. 2008. Novel cytotoxic T-lymphocyte escape mutation by a three-amino-acid insertion in human immunodeficiency virus type 1 p6Pol and p6Gag late domain associated with drug resistance. Journal of Virology 82: 495-502 [pubmed | hubmed].

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  • Liu, Y., J. McNevin, H. Zhao, D. M. Tebit, R. M. Troyer, M. McSweyn, A. K. Ghosh, D. Shriner, E. J. Arts, M. J. McElrath, and J. I. Mullins. 2007. Evolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: fitness-balanced escape. Journal of Virology 81: 12179-12188 [pubmed | hubmed].
  • Deng, W., D. C. Nickle, G. H. Learn, B. Maust, and J. I. Mullins. 2007. ViroBLAST: A stand-alone BLAST web server for flexible queries of multiple databases and user's datasets. Bioinformatics 23: 2334-2336 [pubmed | hubmed].
  • Rolland, M., D. C. Nickle, W. Deng, N. Frahm, C. Brander, G. H. Learn, D. Heckerman, N. Jojic, V. Jojic, B. D. Walker, and J. I. Mullins. 2007. Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins. PLoS ONE 2: e823 [pubmed | hubmed].
  • Rolland, M., M. A. Jensen, D. C. Nickle, J. Yan, G. H. Learn, L. Heath, D. Weiner, and J. I. Mullins. 2007. Reconstruction and function of ancestral Center-of-Tree (COT) human immunodeficiency virus type 1 proteins. Journal of Virology 81: 8507-8514 [pubmed | hubmed].
  • Gottlieb, G. S., D. C. Nickle, M. A. Jensen, K. G. Wong, R. A. Kaslow, J. C. Shepherd, J. B. Margolick, and J. I. Mullins. 2007. HIV type 1 superinfection with a dual-tropic virus and rapid progression to AIDS: a case report. Clinical Infectious Diseases 45: 501-509 [pubmed | hubmed].
  • Crawford, H., J. G. Prado, A. Leslie, S. Hué, I. Honeyborne, S. Reddy, M. van der Stok, Z. Mncube, C. Brander, C. Rousseau, J. I. Mullins, R. Kaslow, P. Goepfert, S. Allen, E. Hunter, J. Mulenga, P. Kiepiela P, B. D. Walker, and P. J. R. Goulder. 2007. Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency type 1 infection. Journal of Virology 81: 8346-8351 [pubmed | hubmed | erratum].
  • Nickle, D. C., L. Heath, M. A. Jensen, P. B. Gilbert, J. I. Mullins, S. L. Kosakovsky Pond. 2007. HIV-specific probabilistic models of protein evolution. PLoS ONE 2: e503 [pubmed | hubmed].
  • Chun, T.-W., J. S. Justement, S. Moir, C. W. Hallahan, J. Maenza, J. I. Mullins, A. C. Collier, L. Corey, and A. S. Fauci. 2007. Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: Implications for eradication of virus. Journal of Infectious Diseases 195: 1762-1764 [pubmed | hubmed].
  • Malhotra, U., F. Li, J. Nolin, M. Allison, H. Zhao, J. I. Mullins, S. Self, and M. J. McElrath. 2007. Enhanced detection of human immunodeficiency virus type 1 (HIV-1) Nef-specific T cells recognizing multiple variants in early HIV-1 infection. Journal of Virology 81: 5225-5237 [pubmed | hubmed].
  • Rousseau, C. M., G. H. Learn, T. Bhattacharya, D. C. Nickle, D. Heckerman, S. Chetty, C. Brander, P. J. Goulder, B. D. Walker, P. Kiepiela, B. T. Korber, and J. I. Mullins. 2007. Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections. Journal of Virology 81: 4492-4500 [pubmed | hubmed | supplemental info].
  • Bhattacharya, T., M. Daniels, D. Heckerman, B. Foley, N. Frahm, C. Kadie, J. Carlson, K. Yusim, B. McMahon, B. Gaschen, S. Mallal, J. I. Mullins, D. C. Nickle, J. Herbeck, C. Rousseau, G. H. Learn, T. Miura, C. Brander, B. Walker, and B. Korber. 2007. Founder effects in the assessment of HIV polymorphisms and HLA allele associations Science 135: 1583-1586 [pubmed | hubmed].
  • Honeyborne, I., A. Prendergast, F. Pereyra, A. Leslie, H. Crawford, R. Payne, S. Reddy, K. Bishop, E. Moodley, K. Nair, M. van der Stok, N. McCarthy, C. M. Rousseau, M. Addo, J. I. Mullins, C. Brander, P. Kiepiela, B. D. Walker, and P. J. Goulder. 2007. Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple Gag-specific CD8+ T-cell epitopes. Journal of Virology 81: 3667-3672 [pubmed | hubmed].
  • Gottlieb, G. S., S. E. Hawes, D. C. Nickle, J. T. Herbeck, N. B. Kiviat, J. I. Mullins, and P. S. Sow. 2007. Presenting plasma HIV RNA level and rate of CD4 T-cell decline. Journal of the American Medical Association 297: 805 [pubmed | hubmed].
  • Kiepiela, P., K. Ngumbela, C. Thobakgale, D. Ramduth, I. Honeyborne, E. Moodley, S. Reddy, C. de Pierres, Z. Mncube, N. Mkhwanazi, K. Bishop, M. van der Stok, K. Nair, N. Khan, H. Crawford, R. Payne, A. Leslie, J. Prado, A. Prendergast, J. Frater, N. McCarthy, C. Brander, G. H. Learn, D. Nickle, C. Rousseau, H. Coovadia, J. I. Mullins, D. Heckerman, B. D. Walker, and P. Goulder. 2007. CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nature Medicine 13: 46-53 [pubmed | hubmed].
  • Malhotra, U., J. Nolin, J. I. Mullins, and M. J. McElrath. 2007. Comprehensive epitope analysis of cross-clade Gag-specific T-cell responses in individuals with early HIV-1 infection in the US epidemic. Vaccine 25: 381-390 [pubmed | hubmed].

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  • Leslie, A., D. A. Price, P. Mkhize, K. Bishop, A. Rathod, C. Day, H. Crawford, I. Honeyborne, T. E. Asher, G. Luzzi, A. Edwards, C. M. Rousseau, J. I. Mullins, G. Tudor-Williams, V. Novelli, C. Brander, D. C. Douek, P. Kiepiela, B. D. Walker, and P. J. Goulder. 2006. Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. Journal of Immunology 177: 4699-4708 [pubmed | hubmed].
  • Liu, Y., J. McNevin, J. Cao, H. Zhao, I. Genowati, K. Wong, S. McLaughlin, M. D. McSweyn, K. Diem, C. E. Stevens, J. Maenza, H. He, D. C. Nickle, D. Shriner, S. E. Holte, A. C. Collier, L. Corey, M. J. McElrath, and J. I. Mullins. 2006. Selection on the human immunodeficiency virus type 1 proteome following primary infection. Journal of Virology 80: 9519-9529 [pubmed | hubmed | supplemental info].
  • Shriner, D., Y. Liu, D. C. Nickle, and J. I. Mullins. 2006. Evolution of intrahost HIV-1 genetic diversity during chronic infection. Evolution 60: 1165-1176 [pubmed | hubmed].
  • Rousseau, C. M., B. A. Birditt, A. R. McKay, J. N. Stoddard, T. C. Lee, S. McLaughlin, S. W. Moore, N. Shindo, G. H. Learn, B. T. Korber, C. Brander, P. J. R. Goulder, P. Kiepiela, B. D. Walker, and J. I. Mullins. 2006. Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. Journal of Virological Methods 136: 118-125 [pubmed | hubmed].
  • Mullins, J. I., and M. A. Jensen. 2006. Evolutionary dynamics of HIV-1 and the control of AIDS. Current Topics in Microbiology and Immunology 299:171-192. [pubmed | hubmed].
  • Holte, S. E., A. J. Melvin, J. I. Mullins, N. H. Tobin, and L. M. Frenkel. 2006. Density-dependent decay in HIV-1 dynamics. Journal of Acquired Immune Deficiency Syndromes 41:266-276. [pubmed | hubmed].
  • Martinez-Picado, J., J. G. Prado, E. E. Fry, K. Pfafferott, A. Leslie, S. Chetty, C. Thobakgale, I. Honeyborne, H. Crawford, P. Matthews, T. Pillay, C. Rousseau, J. I. Mullins, C. Brander, B. D. Walker, D. I. Stuart, P. Kiepiela, and P. Goulder. 2006. Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1. Journal of Virology 80: 3617-3623 [pubmed | hubmed].
  • Liu, Y., J. I. Mullins, and J. E. Mittler. 2006. Waiting times for the appearance of cytotoxic T-lymphocyte escape mutants in chronic HIV-1 infection. Virology 347:140-146 [pubmed | hubmed].
  • Iversen, A. K., G. Stewart-Jones, G. H. Learn, N. Christie, C. Sylvester-Hviid, A. E. Armitage, R. Kaul, T. Beattie, J. K. Lee, Y. Li, P. Chotiyarnwong, T. Dong T, X. Xu, M. A. Luscher, K. MacDonald, H. Ullum, B. Klarlund-Pedersen, P. Skinøj, L. Fugger, S. Buus, J. I. Mullins, E. Y. Jones, P. A. van der Merwe, and A. J. McMichael. 2006. Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope. Nature Immunology 7: 179-189 [pubmed | hubmed].
  • Frahm, N., P. Kiepiela, S. Adams, C. H. Linde, H. S. Hewitt, K. Sango, M. E. Feeney, M. M. Addo, M. Lichterfeld, M. P. Lahaie, E. Pae, A. G. Wurcel, T. Roach, M. A. St John, M. Altfeld, F. M. Marincola, C. Moore, S. Mallal, M. Carrington, D. Heckerman, T. M. Allen, J. I. Mullins, B. T. Korber, P. J. R. Goulder, B. D. Walker, and C. Brander. 2006. Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes. Nature Immunology 7: 173-178 [pubmed | hubmed].

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  • Chun, T.-W., D. C. Nickle, J. S. Justement, D. Large, A. Semerjian, M. E. Curlin, M. A. O'Shea, C. W. Hallahan, M. Daucher, D. J. Ward, S. Moir, J. I. Mullins, C. Kovacs, and A. S. Fauci. 2005. HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. Journal of Clinical Investigation 115: 3250-3255 [pubmed | hubmed].
  • Doria-Rose, N. A., G. H. Learn, A. G. Rodrigo, D. C. Nickle, F. Li, M. Mahalanabis, M. T. Hensel, S. McLaughlin, P. F. Edmonson, D. Montefiori, S. W. Barnett, N. L. Haigwood, and J. I. Mullins. 2005. Human immunodeficiency virus type 1 subtype B ancestral Envelope protein is functional and elicits neutralizing antibodies in rabbits similar to those elicited by a circulating subtype B Envelope. Journal of Virology 79: 11214-11224 [pubmed | hubmed | supplemental info].
  • van 't Wout, A. B., J. V. Swain, M. Schindler, U. Rao, M. S. Pathmajeyan, J. I. Mullins, and F. Kirchhoff. 2005. Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells. Journal of Virology 79: 10053-10058 [pubmed | hubmed].
  • Tobin, N. H., G. H. Learn, S. E. Holte, Y. Wang, A. J. Melvin, J. L. McKernan, D. M. Pawluk, K. M. Mohan, P. F. Lewis, J. I. Mullins, and L. M. Frenkel. 2005. Evidence that low-Level viremias during effective highly active antiretroviral therapy result from two processes: Expression of archival virus and replication of virus. Journal of Virology 79: 9625-9634 [pubmed | hubmed | supplemental info].
  • Troyer, R. M., K. R. Collins, A. Abraha, E. Fraundorf, D. M. Moore, R. W. Krizan, Z. Toossi, R. L. Colebunders, M. A. Jensen, J. I. Mullins, G. Vanham, and E. J. Arts. 2005. Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression. Journal of Virology 79: 9006-9018 [pubmed | hubmed].
  • Gottlieb, G. S., and D. C. Nickle. 2005. Multidrug-resistant, dual-tropic HIV-1 and rapid progression. Lancet 365: 1923-1924 [pubmed | hubmed].
  • Iversen, A. K. N., G. H. Learn, P. Skinhøj, J. I. Mullins, A. J. McMichael, and A. Rambaut. 2005. Preferential detection of HIV subtype C' over subtype A in cervical cells from a dually-infected woman. AIDS 19: 990-993 [pubmed | hubmed].
  • Leslie, A., D. Kavanagh, I. Honeyborne, K. Pfafferott, C. Edwards, T. Pillay, L. Hilton, C. Thobakgale, D. Ramduth, R. Draenert, S. Le Gall, G. Luzzi, A. Edwards, C. Brander, A. K. Sewell, S. Moore, J. Mullins, C. Moore, S. Mallal, N. Bhardwaj, K. Yusim K, R. Phillips, P. Klenerman, B. Korber, P. Kiepiela, B. Walker, and P. Goulder. 2005. Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA. Journal of Experimental Medicine 201: 891-902 [pubmed | hubmed].

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  • Learn, G. H., and J. I. Mullins. 2004. The microbial forensic use of HIV sequences. pp. 22-37. In HIV Sequence Compendium 2003 T. Leitner, B. Foley, B. Hahn, P. Marx, F. McCutchan J. Mellors, S. Wolinksy, and B. Korber, (eds.), Los Alamos National Laboratory, Los Alamos, NM.
  • Kiepiela, P., A. J. Leslie, I. Honeyborne, D. Ramduth, C. Thobakgale, S. Chetty, P. Rathnavalu, C. Moore, K. J. Pfafferott, L. Hilton, P. Zimbwa, S. Moore, T. Allen, C. Brander, M. M. Addo, M. Altfeld, I. James, S. Mallal, M. Bunce, L. D. Barber, J. Szinger, C. Day, P. Klenerman, J. Mullins, B. Korber, H. M. Coovadia, B. D. Walker and P. J. R. Goulder. 2004. Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature 432: 769-775 [pubmed | hubmed].
  • Iversen, A. K. N., J. Attermann, J. Gerstoft, L. Fugger, J. I. Mullins and P. Skinhøj. 2004. Longitudinal and cross-sectional studies of HIV-1 RNA and DNA loads in blood and the female genital tract. European Journal of Obstetrics and Gynecology and Reproductive Biology 117: 227-235 [pubmed | hubmed].
  • Curlin, M. E., G. S. Gottlieb, S. E. Hawes, P. S. Sow, I. Ndoye, C. W. Critchlow, N. B. Kiviat and J. I. Mullins. 2004. No evidence for recombination between HIV type 1 and HIV type 2 within the envelope region in dually seropositive individuals from Senegal. AIDS Research and Human Retroviruses 20: 958-963 [pubmed | hubmed].
  • Liu, Y., D. C. Nickle, D. Shriner, M. A. Jensen, G. H. Learn, Jr., J. E. Mittler and J. I. Mullins 2004. Molecular clock-like evolution of human immunodeficiency virus type 1. Virology 329: 101-108 [pubmed | hubmed].
  • Mullins, J. I., D. C. Nickle, L. Heath, A. G. Rodrigo, and G. H. Learn. 2004. Immunogen sequence: the fourth tier of AIDS vaccine design. Expert Review of Vaccines 3: S151-159 [pubmed | hubmed].
  • Fulcher, J. A., Y. Hwangbo, R. Zioni, D. Nickle, X. Lin, L. Heath, J. I. Mullins, L. Corey, and T. Zhu. 2004. Compartmentalization of human immunodeficiency virus type 1 between blood monocytes and CD4+ T cells during infection. Journal of Virology 78: 7883-7893 [pubmed | hubmed].
  • Zhu, T., S.-L. Hu, F. Feng, P. Polacino, H. Liu, Y. Hwangbo, G. H. Learn, J. I. Mullins, and L. Corey. 2004. Persistence of low levels of simian immunodeficiency virus in macaques that were transiently viremic by conventional testing. Virology 323: 208-219 [pubmed | hubmed].
  • Yu, X. G., M. M. Addo, B. A. Perkins, F. Wej, A. Rathod, S. C. Geer, M. Parta, D. Cohen, D. R. Stone, C. J. Russell, G. Tanzi, S, Mei, A. G. Wurcel, N. Frahm, M. Lichterfeld, L. Heath, J. I. Mullins, F. Marincola, P. J. R. Goulder, C. Brander, T. Allen, Y. Cao, B. D. Walker, and M. Altfeld. 2004. Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and Caucasians. AIDS Research and Human Retroviruses 20: 557-564 [pubmed | hubmed].
  • Shriner, D., R. Shankarappa, M. A. Jensen, D. C. Nickle, J. E. Mittler, J. B. Margolick, and J. I. Mullins. 2004. Influence of random genetic drift on human immunodeficiency virus type 1 env evolution during chronic infection. Genetics 166: 1155-1164 [pubmed | hubmed].
  • Frahm, N., B.T. Korber, C. M. Adams, J. J. Szinger, R. Draenert, M. M. Addo, M. E. Feeney, K. Yusim, K. Sango, N. V. Brown, D. SenGupta, A. Piechocka-Trocha, T. Simonis, F. M. Marincola, A. G. Wurcel, D. R. Stone, C. J. Russell, P. Adolf, D. Cohen, T. Roach, A. StJohn, A. Khatri, K. Davis, J. Mullins, P. J. Goulder, B. D. Walker, and C. Brander. 2004. Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. Journal of Virology 78: 2187-2200 [pubmed | hubmed].
  • Brumme, Z. L., W. W. Dong, B. Yip, B. Wynhoven, N. G. Hoffman, R. Swanstrom, M. A. Jensen, J. I. Mullins, R. S. Hogg, J. S. Montaner, and P. R. Harrigan. 2004. Clinical and immunological impact of HIV envelope V3 sequence variation after starting initial triple antiretroviral therapy. AIDS 18: F1-F9 [pubmed | hubmed].
  • Gottlieb, G. S., D. C. Nickle, M. A. Jensen, K. G. Wong, J. Grobler, F. Li, S.-L. Liu, C. Rademeyer, G. H. Learn, S. S. A. Karim, C. Williamson, L. Corey, J. B. Margolick, and J. I. Mullins. 2004. Dual HIV-1 infection associated with rapid disease progression. The Lancet 363: 619-622 [pubmed | hubmed | supplemental info].

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  • Jensen, M. A., F.-S. Li, A. B. van 't Wout, D. C. Nickle, D. Shriner, H.-X. He, S. McLaughlin, R. Shankarappa, J. B. Margolick, and J. I. Mullins. 2003. Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of HIV-1 env V3 loop sequences. Journal of Virology 77: 13376-13388 [pubmed | hubmed | supplemental info].
  • Altfeld, M., M. M. Addo, R. Shankarappa, P. K. Lee, T. M. Allen, X. G. Yu, A. Rathod, J. Harlow, K. O'Sullivan, M. N. Johnston, P. J. R. Goulder, J. I. Mullins, E. S. Rosenberg, C. Brander, B. Korber, and B. D. Walker. 2003. Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences. Journal of Virology 77: 7330-7340 [pubmed | hubmed].
  • Zhu, T., L. Corey, Y. Hwangbo, J. M. Lee, G. H. Learn, J. I. Mullins, and M. J. McElrath. 2003. Persistence of extraordinarily low levels of genetically homogeneous human immunodeficiency virus type 1 in exposed seronegative individuals. Journal of Virology 77: 6108-6116 [pubmed | hubmed].
  • Frenkel, L. M., Y. Wang, G. H. Learn, J. L. McKernan, G. M. Ellis, K. M. Mohan, S. E. Holte, S. M. De Vange, D. M. Pawluk, A. J. Melvin, P. F. Lewis, L. M. Heath, I. A. Beck, M. Mahalanabis, W. E. Naugler, N. H. Tobin, and J. I. Mullins. 2003. Multiple viral genetic analyses detect low-level human immunodeficiency virus type 1 replication during effective highly active antiretroviral therapy. Journal of Virology 77: 5721-5730 [pubmed | hubmed | supplemental info].
  • Shriner, D., D. C. Nickle, M. A. Jensen, and J. I. Mullins. 2003. Potential impact of recombination on sitewise approaches for detecting positive natural selection. Genetical Research 81: 115-121 [pubmed | hubmed].
  • Nickle, D. C., M. A. Jensen, D. Shriner, S. J. Brodie, L. M. Frenkel, J. E. Mittler, and J. I. Mullins. 2003. Evolutionary indicators of human immunodeficiency virus type 1 reservoirs and compartments. Journal of Virology 77: 5540-5546 [pubmed | hubmed].
  • Nickle, D. C., M. A. Jensen, G. S. Gottlieb, D. Shriner, G. H. Learn, A. G. Rodrigo, and J. I. Mullins. 2003. Consensus and ancestral state HIV vaccines. Science 299: 1515-1517 [pubmed | hubmed].
  • Dybul, M., M. Daucher, M. A. Jensen, C. W. Hallahan, T.-W. Chun, M. Belson, B. Hidalgo, D. C. Nickle, C. Yoder, J. A. Metcalf, R. T. Davey, L. Ehler, D. Kress-Rock, E. Nies-Kraske, S. Liu, J. I. Mullins, and A. S. Fauci. 2003. Genetic characterization of rebounding human immunodeficiency virus Type 1 in plasma during multiple interruptions of highly active antiretroviral therapy. Journal of Virology 77: 3229-3237 [pubmed | hubmed].

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  • Learn, G. H., D. Muthui, S. J. Brodie, T. Zhu, K. Diem, J. I. Mullins, and L. Corey. 2002. Virus population homogenization following acute human immunodeficiency virus type 1 infection. Journal of Virology 76: 11953-11959 [pubmed | hubmed].
  • Liu, S.-L., J. E. Mittler, D. C. Nickle, T. M. Mulvania, D. Shriner, A. G. Rodrigo, B. Kosloff, X. He, L. Corey, and J. I. Mullins. 2002. Selection for human immunodeficiency virus type 1 recombinants in a patient with rapid progression to AIDS. Journal of Virology 76: 10674-10684 [pubmed | hubmed].
  • Malaspina, A., S. Moir, D. C. Nickle, E. T. Donoghue, K. M. Ogwaro, L. A. Ehler, S. Liu, J. A. Mican, M. Dybul, T. W. Chun, J. I. Mullins, and A. S. Fauci. 2002. Human immunodeficiency virus type 1 bound to B cells: relationship to virus replicating in CD4+ T cells and circulating in plasma. Journal of Virology 76: 8855-8863 [pubmed | hubmed].
  • Gottlieb, G., P. S. Sow, S. E. Hawes, I. Ndoye, M. Redman, A. M. Coll-Seck, M. A. Faye-Niang, A. Diop, J. M. Kuypers, C. W. Critchlow, R. Respess, J. I. Mullins, and N. B. Kiviat. 2002. Equal plasma viral loads predict a similar rate of CD4+ T cell decline in human immunodeficiency virus (HIV) type 1 and HIV-2 infected individuals from Senegal, West Africa. Journal of Infectious Diseases 185: 905-914 [pubmed | hubmed].
  • Zhu, T., D. Muthui, S. Holte, D. Nickle, F. Feng, S. Brodie, Y. Hwangbo, J. I. Mullins, and L. Corey. 2002. Evidence for human immunodeficiency virus type 1 replication in vivo in CD14+ monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy. Journal of Virology 76: 707-716 [pubmed | hubmed].
  • Li, F, and J. I. Mullins. 2002. Site-directed mutagenesis facilitated by DpnI selection on hemimethylated DNA. Methods in Moleclar Biology 182: 19-27 [pubmed | hubmed].
  • Anderson, J. P., M. Rain, D. Shriner, A. G. Rodrigo, Y. Wang, D. Nickle, G. H. Learn, W. E. Naugler and J. I. Mullins. 2002. The genetics of HIV-1. pp. 44-99. In The Human Immunodeficiency Virus. E. A. Emini (ed.), Princeton University Press, Princeton, N.J.

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  • Shankarappa, R., R. Chatterjee, G. H. Learn, D. Neogi, M. Ding, P. Roy, A. Ghosh, L. Kingsley, L. Harrison, J. I. Mullins and P. Gupta. 2001. Human immunodeficiency virus type 1 (HIV-1) env sequences from Calcutta in Eastern India: Identification of features that distinguish subtype C sequences in India from other subtype C sequences. Journal of Virology 75: 10479-10487 [pubmed | hubmed].
  • Holterman, L., R. Dubbes, J. Mullins, G. Learn, H. Niphuis, W. Koornstra, G. Koopman, E.-M. Kuhn, A. Wade-Evans, B. Rosenwirth, J. Haaijman and J. Heeney. 2001. Distinct characteristics of a pathogenic molecular clone of an end-stage variant of simian immunodeficiency virus (SIVF359). Journal of Virology 75: 9328-9338 [pubmed | hubmed].
  • Kreisberg, J. F., D. Kwa, B. Schramm, V. Trautner, R. Connor, H. Schuitemaker, J. I. Mullins, A. B. van 't Wout, and M. A. Goldsmith. 2001. Cytopathicity of human immunodeficiency virus type 1 primary isolates depends on coreceptor usage and not patient disease status. Journal of Virology 75: 8842-8847 [pubmed | hubmed].
  • Anderson, J. P., A. G. Rodrigo, G. H. Learn, Y. Wang, H. Weinstock, M. L. Kalish, K. E. Robbins, L. Hood, and J. I. Mullins. 2001. Substitution model of sequence evolution for the human immunodeficiency virus type 1 subtype B gp120 gene over the C2-V5 region. Journal of Molecular Evolution 53: 55-62 [pubmed | hubmed].
  • Gottlieb, G. S., and J. I. Mullins. 2001. Re: Follow-up study of intrahost HIV type 2 variability reveals discontinuous evolution of C2V3 sequences. AIDS Research and Human Retroviruses 17: 253-256 [pubmed | hubmed].
  • Frenkel, L. M., and J. I. Mullins. 2001. Should patients with drug-resistant HIV-1 continue to receive antiretroviral therapy? New England Journal of Medicine 344: 520-522 [pubmed | hubmed].
  • Altfeld, M., E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. 2001. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. Journal of Experimental Medicine 193: 169-180 [pubmed | hubmed].
  • Rodrigo, A. G., and G. H. Learn, Jr. (editors) 2001. Computational and Evolutionary Analyses of HIV Sequences. Kluwer Academic Publishers, Boston.
  • Rodrigo, A. G., E. W. Hanley, P. C. Goracke, and G. H. Learn, Jr. 2001. Sampling and processing HIV molecular sequences: a computational evolutionary biologist's perspective. pp. 1-17. In Computational and Evolutionary Analyses of HIV Sequences. A. G. Rodrigo and G. H. Learn, Jr. (eds.), Kluwer Academic Publishers, Boston.
  • Beerli, P., N. C. Grassly, M. K. Kuhner, D. Nickle, O. Pybus, M. Rain, A. Rambaut, A. G. Rodrigo, and Y. Wang. 2001. Population genetics of HIV: Parameter estimation using genealogy-based methods. pp. 217-258. In Computational and Evolutionary Analyses of HIV Sequences. A. G. Rodrigo and G. H. Learn, Jr. (eds.), Kluwer Academic Publishers, Boston.

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  • Anderson, J. P., A. G. Rodrigo, G. H. Learn, A. Madan, C. Delahunty, M. Coon, M. Girard, S. Osmanov, L. Hood, and J. I. Mullins. 2000. Testing the hypothesis of a recombinant origin of human immunodeficiency virus type 1 subtype E. Journal of Virology 74: 10752-10765 [pubmed | hubmed].
  • Russell, K. L., C. Carcamo, D. M. Watts, J. Sanchez, E. Gotuzzo, A. Euler, J. C. Blanco, A. Galeano, A. Alava, J. I. Mullins, K. K. Holmes, and J. K. Carr. 2000. Emerging genetic diversity of HIV-1 in South America. AIDS 14: 1785-1791 [pubmed | hubmed].
  • Chun, T. W., R. T. Davey, Jr, M. Ostrowski, J. Shawn Justement, D. Engel, J. I. Mullins, and A. S. Fauci. 2000. Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy. Nature Medicine 6: 757-761 [pubmed | hubmed].
  • Robertson, D. L., J. P. Anderson, J. A. Bradac, J. K. Carr, B. Foley, R .K. Funkhouser, F. Gao, B. H. Hahn, M. L. Kalish, C. Kuiken, G. H. Learn , T. Leitner, F. McCutchan, S. Osmanov, M. Peeters, D. Pieniazek, M. Salminen, P. M. Sharp, S. Wolinsky, and B. Korber. 2000. HIV-1 nomenclature proposal: A reference guide to HIV-1 classification. pp. 492-505. In Human Retroviruses and AIDS 1999: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences. C. L. Kuiken, B. Foley, B. Hahn, B. Korber, F. McCutchan, P. A. Marx, J. W. Mellors, J. I. Mullins, J. Sodroski, and S. Wolinksy (eds.), Los Alamos National Laboratory, Los Alamos, NM.
  • Robertson, D. L., J. P. Anderson, J. A. Bradac, J. K. Carr, B. Foley, R. K. Funkhouser, F. Gao, B. H. Hahn, M. L. Kalish, C. Kuiken, G. H. Learn , T. Leitner, F. McCutchan, S. Osmanov, M. Peeters, D. Pieniazek, M. Salminen, P. M. Sharp, S. Wolinsky and B. Korber. 2000. HIV-1 nomenclature proposal. Science 288: 55 [pubmed | hubmed].
  • Panther, L. A., L. Tucker, C. Xu, R. E. Tuomala, J. I. Mullins, and D. J. Anderson. 2000. Genital tract human immunodeficiency virus type 1 (HIV-1) shedding and inflammation and HIV-1 env diversity in perinatal HIV-1 transmission. Journal of Infectious Diseases 181: 555-563 [pubmed | hubmed].
  • Geiss, G. K., R. E. Bumgarner, M. C. An, M. B. Agy, A. B. van 't Wout, E. Hammersmark, V. S. Carter, D. Upchurch, J. I. Mullins, and M. G. Katze. 2000. Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays. Virology 266: 8-16 [pubmed | hubmed].

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  • Mulvania, T., J. B. Lynch, M. N. Robertson, P. D. Greenberg, W. R. Morton, and J. I. Mullins. 1999. Antigen-specific cytokine responses in vaccinated Macaca nemestrina. Journal of Medical Primatology 28: 181-189 [pubmed | hubmed].
  • Li, F., S.-L. Liu, and J. I. Mullins. 1999. Site-directed mutagenesis using uracil-containing double-stranded DNA templates and DpnI digestion. Biotechniques 27: 734-738 [pubmed | hubmed].
  • Shankarappa, R., J. B. Margolick, S. J. Gange, A. G. Rodrigo, D. Upchurch, H. Farzadegan, P. Gupta, C. R. Rinaldo, G. H. Learn, X. He, X.-L. Huang, and J. I. Mullins. 1999. Consistent viral evolutionary changes asscociated with the progression of human immunodeficiency virus type 1 infection. Journal of Virology 73: 10489-10502 [pubmed | hubmed | supplemental info].  
  • Melvin, A. J., A. G. Rodrigo, K. M. Mohan, P. A. Lewis, L. Manns-Arcuino, R. W. Coombs, J. I. Mullins, and L. M. Frenkel. 1999. HIV-1 dynamics in children. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 20: 468-473 [pubmed | hubmed].
  • Tien, P. C., T. Chiu, R. Latif, S. Ray, M. Batra, C. H. Contag, L. Zejena, M. Mbizvo, E. L. Delwart, J. I. Mullins, and D. A. Katzenstein. 1999. Primary subtype C HIV-1 infection in Harare, Zimbabwe. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 20: 147-153 [pubmed | hubmed].
  • Wolinsky, S., and G. H. Learn. 1999. Levels of diversity within and among host individuals. pp. 275-314. In The Evolution of HIV. K. A. Crandall (ed.), Johns Hopkins University Press, Baltimore, MD.

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  • Rinaldo, C. R., Jr, P. Gupta, X. L. Huang, Z. Fan, J. I. Mullins, S. Gange, H. Farzadegan, R. Shankarappa, A. Munoz, and J. B. Margolick. 1998. Anti-HIV type 1 memory cytotoxic T lymphocyte responses associated with changes in CD4+ T cell numbers in progression of HIV type 1 infection. AIDS Research and Human Retroviruses 14: 1423-1433 [pubmed | hubmed].
  • Iversen, A. K., L. Fugger, J. Eugen-Olsen, U. Balslev, T. Jensen, S. Wahl, J. Gerstoft, J. I. Mullins, and P. Skinhøj. 1998. Cervical human immunodeficiency virus type 1 shedding is associated with genital beta-chemokine secretion. Journal of Infectious Diseases 178: 1334-1342 [pubmed | hubmed].
  • Mulvania, T., E. Coon, L. Kuller, M. B. Agy, W. R. Morton, and J. I. Mullins. 1998. Natural history of SIVmac BK28 and H824 infection in Macaca nemestrina. Journal of Medical Primatology 27: 87-93 [pubmed | hubmed].
  • Poss, M., A. G. Rodrigo, J. J. Gosink, G. H. Learn, D. de Vange Panteleeff, H. L. Martin, Jr., J. Bwayo, Joan K. Kreiss, and J. Overbaugh. 1998. Evolution of envelope sequences from the genital tract and peripheral blood of women infected with clade A human immunodeficiency virus type 1. Journal of Virology 72: 8240-8251 [pubmed | hubmed].
  • Ostrowski, M. A., D. C. Krakauer, Y. Li, S. J. Justement, G. Learn, L. A. Ehler, S. K. Stanley, M. Nowak, and A. S. Fauci. 1998. Effect of immune activation on the dynamics of human immunodeficiency virus replication and on the distribution of viral quasispecies. Journal of Virology 72: 7772-7784 [pubmed | hubmed].  
  • Dwyer, D. E., B. L. Herring, Y. C. Ge, W. V. Bolton, R. B. Ellis-Pegler, M. Thomas, B. A. Schroeder, M. C. Croxson, A. L. Cunningham, J. I. Mullins, and N. K. Saksena. 1998. Human immunodeficiency virus type 1 subtypes B and C detected in New Zealand. AIDS Research and Human Retroviruses 10: 1105-1108 [pubmed | hubmed].
  • Frenkel, L., J. I. Mullins, G. H. Learn, L. Manns-Arcuino, B. L. Herring, M. L. Kalish, R. W. Steketee, D. M. Thea, J. E. Nichols, S.-L. Liu, A. Harmache, X. He, D. Muthui, A. Madan, L. Hood, A. T. Haase, M. Zupancic, K. Staskus, S. M. Wolinsky, P. Krogstad, J. Zhao, I. Chen, R. Koup, D. D. Ho, B. T. Korber, R. J. Apple, R. W. Coombs, S. Pahwa, and N. J. Roberts, Jr. 1998. Genetic evaluation of suspected cases of transient HIV-1 infection of infants. Science 280:1073-1077 [pubmed | hubmed | supplemental info].  
  • Iversen, A. K., A. R. Larsen, T. Jensen, L. Fugger, U. Balslev, S. Wahl, J. Gerstoft, J. I. Mullins, and P. Skinhøj. 1998. Distinct determinants of human immunodeficiency virus type 1 RNA and DNA loads in vaginal and cervical secretions. Journal of Infectious Diseases 177: 1214-1220 [pubmed | hubmed].
  • Polyak, S. J., S. McArdle, S.-L. Liu, D. G. Sullivan, M. Chung, W. T. Hofgartner, R. L. Carithers, Jr, B. J. McMahon, J. I. Mullins, L. Corey, and D. R. Gretch. 1998. Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection. Journal of Virology 72: 4288-4296 [pubmed | hubmed].
  • Shankarappa, R., P. Gupta, G. H. Learn, Jr., A. G. Rodrigo, C. R. Rinaldo, Jr., M. C. Gorry, J. I. Mullins, P. L. Nara, and G. D. Ehrlich. 1998.  Evolution of human immunodefiency virus type 1 envelope sequences in infected individuals with differing disease progression profiles.  Virology 241:251-259 [pubmed | hubmed].  
  • Paladin, F. J. E., O. T. Monzon, H. Tsuchie, M. R. A. Aplasca, G. H. Learn, Jr., and T. Kurimura. 1998.  Genetics subtypes of HIV-1 in the Philippines.  AIDS 12: 291-300 [pubmed | hubmed].  
  • Delwart, E. L., J. I. Mullins, P. Gupta, G. H. Learn, Jr., M. Holodniy, D. Katzenstein, B. D. Walker, and M. K. Singh.  1998.  Human immunodeficiency virus type I populations in blood and semen. Journal of Virology 72: 617-623 [pubmed | hubmed].  
  • Edmonson, P., M. Murphey-Corb, L. N. Martin, C. Delahunty, J. Heeney, H. Kornfeld, P. R. Donohue, G. H. Learn, L. Hood, and J. I. Mullins. 1998.  Evolution of a simian immunodeficiency virus pathogen.  Journal of Virology 72: 405-414 [pubmed | hubmed].  

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