Meeting Program

All talks for the meeting were held in Pelton Auditorium at the FHCRC


Friday Morning, April 28, 2000

Welcoming Remarks: Lee Hartwell & Gerald Learn

Session 1: Evolution and Global Variation of HIV and Related Viruses Chairs: David Robertson & Frederick Bibollet-Ruche
8:30-8:55 Paul Sharp, University of Nottingham, UK: Complex Origins of SIV from Red-Capped Mangabeys
8:55-9:20 Frederick Bibollet-Ruche, University of Alabama, Birmingham, USA: Molecular Characterization of Primate Lentiviruses from DeBrazza, Mona and Blue Monkeys
9:20-9:45 Vanessa Hirsch, National Institutes of Health, Rockville, USA: Characterization of SIV from the L'Hoest Superspecies
10:05-10:30 Anne-Mieke Vandamme, University of Leuven, Belgium: Dating the Origin of HIV-1 Group M and HIV-1 Group M/SIVcpz Separation
10:30-10:55 Eric Delaporte, IRD, Montpellier, France: Identification and Molecular Characterization of a New Primate Lentivirus (SIVcol) from Colobus Monkeys in Cameroon
10:55-11:20 Pierre Roques, CRSSA, Fontenay-aux-Roses, France: Molecular Relationship Between HIV-1 Group N and SIVcpz (Pan troglodytes troglodytes) Strains
11:20-11:45 David Robertson, Oxford University, UK: The HIV Nomenclature

Friday Afternoon, April 28, 2000
Session 2: HIV Evolution and Transmission
Chairs: Marcia Kalish & Tom Folks
1:00-1:25 Michaela Muller-Trutwin, Institut Pasteur, Paris, France: Viral Dynamics During Primary SIV Infection in its Natural Host
1:25-1:50 Gabriella Scarlatti, Ospedale San Raffaele, Milan, Italy: Early Detection Of Molecular And Biological Heterogeneity In HIV-1 Isolates From Children With Slow And Fast Disease Progression
1:50-2:15 Thomas Leitner, Karolinska Institute, Solna, Sweden: Competing Subpopulations After Multiple HIV-1 Mother-to-Child Transmission
2:15-2:40 E. Michelle Long, Fred Hutchinson Cancer Research Center, Seattle, USA: Gender Differences In HIV-1 Diversity At Time Of Infection
2:40-3:05 Linqi Zhang, Aaron Diamond AIDS Research Center, New York, USA: Genetic Characterization of the Rebounding HIV-1 after Cessation of HAART
3:25-3:50 Tae-Wook Chun, National Institutes of Health, Bethesda, USA: Relationship Between Pre-Existing Viral Reservoirs and the Re-Emergence of Plasma Viremia Following Discontinuation of Highly Active Antiretroviral Therapy
3:50-4:15 Zvi Grossman, National Cancer Institute, Bethesda, USA: Proximal Immune Activation and HIV Transmission: Implications for HIV Evolution and Transmission

Session 3: Evolution and Drug Resistance Chair: Andrew Leigh Brown
4:15-4:40 Francois Clavel, INSERM, Paris, France: HIV Drug Resistance and Fitness
4:40-5:05 Ronald Swanstrom, University of North Carolina, Chapel Hill, USA: Dynamic Behavior of HIV-1 Populations While Under Strong Selective Pressure
5:05-5:30 Jaap Goudsmit, University of Amsterdam, The Netherlands: Bottleneck Transmission of Nucleoside Analogue-Resistant HIV-1 and the Establishment of New HIV-1 RT Wild Types
5:30-5:55 Charles Boucher, University Hospital, Utrecht, The Netherlands: Difference In Resistance Contribute More Strongly To The Evolution Of Zidovudine Resistance In HIV-1 Infected Patients Than Difference In Replication Capacity

Friday Evening, April 28, 2000
6:45-10:00 Banquet -- Skyline Level, Space Needle
Speaker: Steven Austad, University of Idaho, Moscow, USA:
The Curse of Tithonus: Why Evolution Makes Us Age and What Molecular Biology Can do About It


Saturday Morning, April 29, 2000

Session 4: Lessons from Other Viruses Chair: Avidan U. Neumann
8:45-8:55 Avidan U. Neumann, Bar-Ilan University, Ramat-Gan, Israel: Introduction to Hepatitis C Virus
8:55-9:20 Derek Smith, University of New Mexico, Albuquerque, USA: Variable Efficacy Of Repeated Annual Influenza Vaccination
9:20-9:45 Margaret Koziel, Harvard University, Cambridge, USA: Immunopathogeneis of Hepatitis C Viruses
10:00-10:25 Jean-Michel Pawlotsky, Hopital Henri Mondor, Cretiel, France: Hepatitis C Virus Quasi-species Intra-host Evolution
10:25-10:50 Avidan U. Neumann, Bar-Ilan University, Ramat-Gan, Israel: Clinical Implications of Hepatitis C Virus Dynamics

Session 3: Evolution and Drug Resistance (Cont'd) Chair: Andrew Leigh Brown
10:50-11:15 Jeanette Whitcomb, ViroLogic, South San Francisco, USA: HIV-1 Hypersensitivity to NNRTI is Associated with Reduced Susceptibility to NRTI
11:15-11:40 Andrew Leigh Brown, University of Edinburgh, Scotland: Identifying Mutations with Small Effects on Drug Resistance

Saturday Afternoon, April 29, 2000
Session 5: Viral Variability and the Immune Response Chair: Bette Korber
12:40-1:05 Doug Nixon, Aaron Diamond AIDS Research Center, New York, USA: A Novel Single Cell Flow Based Killing Assay to Measure CTL Responses to Viral Variants
1:05-1:30 David Watkins, University of Wisconsin-Madison, USA: Tat-Specific CTL Responses Select for Escape Variants During Acute SIV Infection
1:30-1:55 Frances Gotch, Chelsea and Westminster Hospital, London, UK: Immune Responses to HIV in Uganda
1:55-2:20 Philip Goulder, Harvard University, Cambridge, USA: Qualitative Differences Between HIV-Specific CTL Responses as Reflected by the Presence or Absence of Epitope-Specific Escape Mutation
2:20-2:45 Jerry Learn, University of Washington, Seattle, USA: The Use of an Inferred Epidemic Ancestral Sequence as a Vaccine Immunogen
2:45-3:10 Bette Korber, Los Alamos National Laboratory, USA: Global Variability of Defined CTL Epitopes

Session 6: Mathematical Modeling of HIV Dynamics and Evolution.
Chairs: John Mittler & Alan Perelson
3:25-3:50 Dimiter Dimitrov, FCRDC, Frederick, USA: Comparative Analysis of HIV/SHIV Dynamics in Cultured Cells, Primary Infections in Monkeys and Humans Off Therapy
3:50-4:15 Bob Grant, University of California San Francisco, USA: Viremia Increases During Treatment Interruption After Long Term Virologic Failure
4:15-4:40 William Hlavacek, Los Alamos National Laboratory, USA: Follicular Dendritic Cells and HIV Dynamics
4:40-5:05 Duncan Callaway, Cornell University, Ithaca, USA: Intermittent Viremia in HIV-1 Infected Patients Receiving Antiretroviral Therapy: A Dynamic Point of View
5:05-5:30 Ruy Ribeiro, Los Alamos National Laboratory, USA: Measuring T-Cell Turnover

Saturday Evening, April 29, 2000
7:00-9:00 Cocktail Hour & Poster Session -- The Double Helix Café, FHCRC

Morning Sunday, April 30, 2000
Session 7: Evolutionary Genetics of HIV Chair: Allen Rodrigo
8:30-8:55 Igor Rouzine, Tufts University, Boston, USA: Stochastic Evolution of a Single Locus in Haploid Population: An Analytic Review
8:55-9:20 Simon Frost, University of Edinburgh, Scotland: Genetic Drift and Within Host Metapopulation Structure in the Evolution of HIV
9:20-9:45 Allen Rodrigo, University of Auckland, New Zealand: Evolutionary Analyses of Serially Sampled Populations
10:10-10:35 Daniel A. Vasco and Keith A. Crandall, Brigham Young University, Provo, USA: Applications of Coalescent Statistical Methods to HIV Data Analysis
10:35-11:00 Rasmus Nielsen, Harvard University, Cambridge, USA: Detecting Selection In The HIV-1 Genome Using the dn/ds Ratio
11:00-11:25 Yun-Xin Fu, University of Texas at Houston, USA: Estimating the Generation Time of Within-Host HIV Populations
11:25-11:50 Jim Mullins, University of Washington, Seattle, USA: Measuring In-Vivo Migration and Compartmentalization of HIV



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