Bull M, McKernan J, Styrchak S, Kraft K, Hitti J, Cohn SE, Tapia K, Deng W, Holte S, Mullins JI, Coombs RW, Frenkel L (2019). Phylogenetic analyses comparing HIV sequences from plasma at virologic failure to cervix vs. blood sequences from antecedent antiretroviral therapy suppression. AIDS research and human retroviruses (ePub ahead of print). (pubmed) (doi)
Identifying tissue sources of HIV that rebound following “failure” of antiretroviral therapy (ART) is critical to evaluating cure strategies. To assess the role of the uterine cervix and peripheral blood mononuclear cells (PBMC) as viral reservoirs, nearest-neighbor phylogenetic analyses compared genetic relatedness of tissue sequences during ART-suppression to those detected in plasma at viral rebound.