This page is part of a copy of HIRIS frozen in time on 26 October 2017. The permanent URL of this frozen version is: https://mullinslab.microbiol.washington.edu/hiris/frozen/Edlefsen_et_al_2018/.
If you’re not using this frozen version for analysis, you may want to switch to the latest version.
HIRIS: HIV-1 Reservoirs Integration Sites “high-rise”
HIRIS aims to provide a stable, authoritative, and standardized source of data for analysing HIV-1 integration sites from the viral reservoir. It seeks to support analyses using the tools of your choice, whether that’s R and ggplot or Excel and Prism.
The data contained within comes from a variety of published sources curated by the Mullins Lab. The database itself is regularly and automatically regenerated from our primary and secondary sources in order to incorporate changes and additions.
If you’d like to see your HIV-1 integration site data included, please email us.
Similar resources
A few other curated datasets of viral integration sites exist. You may find that some of them better fit your needs.
- Retrovirus Integration Database (RID), a project of the National Cancer Institute HIV Dynamics and Replication Program, collects published data on HIV-1, HTLV-1, and MLV integration sites. Some of the data in HIRIS is derived from the RID dataset, and we gratefully acknowledge their prior work.
- Dr. VIS is a clinically-focused database of disease-related viral integration sites.
- RTCGD: Retrovirus and Transposon tagged Cancer Gene Database aggregates viral integration sites derived from mouse tumor model experiments.
Top 12 in vivo genes by # of Subjects and Unique IS
See an expanded version of this plot on the Top Genes page.
| Rank | Gene | # of Subjects | Unique IS | Total IS |
|---|---|---|---|---|
| 1 | STAT5B | 12 | 25 | 45 |
| 2 | RPTOR | 12 | 14 | 47 |
| 3 | BACH2 | 10 | 67 | 112 |
| 4 | SMG1P5 | 10 | 15 | 15 |
| 5 | TNRC6C | 10 | 14 | 14 |
| 6 | NFATC3 | 10 | 12 | 14 |
| 7 | SAE1 | 10 | 10 | 10 |
| 8 | CYTH1 | 9 | 13 | 13 |
| 9 | NSD1 | 9 | 12 | 15 |
| 10 | ASH1L | 8 | 11 | 11 |
| 11 | PACS1 | 7 | 13 | 13 |
| 12 | MKL1 | 7 | 10 | 15 |
Copyright © 2015–2017 University of Washington. Previously published datasets are copyright their respective authors and used in accordance with their licenses.
This work was supported by the National Institutes of Health [R01AI111806, R21AI22361].
Built with ISDB, a project of the Mullins Molecular Retrovirology Lab at the University of Washington.