Mullins Molecular Retrovirology Lab
The Mullins laboratory is located in the Rosen Building on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.
RV144 Analysis Featured by Nature
Step Trial Analysis Featured in UW Today
Improved Detection of Rare HIV-1 Variants using 454 Pyrosequencing.
Quality score based identification and correction of pyrosequencing errors.
Inferring viral population structures using heteroduplex mobility and DNA sequence analyses.
Journal of virological methods1941-2169-177
Indel and Carryforward Correction (ICC): a new analysis approach for processing 454 pyrosequencing data.
Bioinformatics (Oxford, England)29192402-9
Selective Induction of CTL Helper Rather Than Killer Activity by Natural Epitope Variants Promotes Dendritic Cell-Mediated HIV-1 Dissemination.
Journal of immunology (Baltimore, Md. : 1950)19152570-80
Department of Microbiology
School of Medicine
University of Washington