Mullins Molecular Retrovirology Lab
The Mullins laboratory is located in the Rosen Building on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.
RV144 Analysis Featured by Nature
Step Trial Analysis Featured in UW Today
Thor A. Wagner, Sherry McLaughlin, Kavita Garg, Charles Y. K. Cheung, Brendan B. Larsen, Sheila Styrchak, Hannah C. Huang, Paul T. Edlefsen, James I. Mullins, Lisa M. Frenkel 2014 Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection Science DOI:10.1126/science.1256304 Link
HIV-1 superinfection with a triple-class drug-resistant strain in a patient successfully controlled with antiretroviral treatment.
AIDS (London, England)Epub ahead of print
Dendritic cells restore CD8+ T cell reactivity to autologous HIV-1.
Journal of virologyEpub ahead of print
An HIV Epidemic Model Based on Viral Load Dynamics: Value in Assessing Empirical Trends in HIV Virulence and Community Viral Load.
PLoS computational biology106e1003673
Analysis of HLA A*02 Association with Vaccine Efficacy in the RV144 HIV-1 Vaccine Trial.
Journal of virology88158242-8255
Department of Microbiology
School of Medicine
University of Washington