Mullins Molecular Retrovirology Lab
The Mullins laboratory is located in the Rosen Building on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.
RV144 Analysis Featured by Nature
Step Trial Analysis Featured in UW Today
Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design.
Complex patterns of protease inhibitor resistance among antiretroviral treatment-experienced HIV-2 patients from Senegal: Implications for second-line therapy.
Antimicrobial agents and chemotherapyEpub ahead of print
HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice.
HIV-1 conserved elements vaccines: Relationship between sequence conservation and replicative capacity.
Journal of VirologyEpub ahead of print
Human Immunodeficiency Viruses Appear Compartmentalized to the Female Genital Tract in Cross-Sectional Analyses, but Genital Lineages Do Not Persist Over Time.
The Journal of Infectious DiseasesEpub ahead of print
Department of Microbiology
School of Medicine
University of Washington