Mullins Molecular Retrovirology Lab

  • Department of Microbiology
  • School of Medicine
  • University of Washington

Citation Information

Liu Y, Curlin ME, Diem K, Zhao H, Ghosh AK, Zhu H, Woodward AS, Maenza J, Stevens CE, Stekler J, Collier AC, Genowati I, Deng W, Zioni R, Corey L, Zhu T, Mullins JI (2008). Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses. Virology, 374(2), 229-33. (pubmed) (doi)

Abstract

Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites.

Supplemental Data

Study Pairs and Associated GenBank Accession Numbers

Pair

Patient ID (GB Patient ID)

Donor or Recipient

Assess number

A

68398 (293)

D

EU588870

to

EU588883

25521 (301)

R

EU588884

to

EU588896

B

84285 (138)

D

EU588908

to

EU588921

94959 (139)

R

EU588922

to

EU588935

C

34287 (831)

D

EU588818

to

EU588832

26803 (558)

R

EU588804

to

EU588817

D

XXX PX84 (1574)

D

EU588950

to

EU588968

90114 (124)

R

EU588897

to

EU588907

E

45534 (391)

D

EU588748

to

EU588762

88234 (392)

R

EU588732

to

EU588747

F

37628 (860)

D

EU915533

to

EU915547

64236 (164)

R

EU915518

to

EU915532

G

SNONP 0033 (3794)

D

EU588936

to

EU588949

64428 (290)

R

EU588857

to

EU588869

H

1365 58368 (829)

D

EU588793

to

EU588803

 

 

DQ853455

to

DQ853464

1362 87014 (82)

R

EU588786

to

EU588792

 

 

DQ853426

to

DQ853435

I

30627 (839)

D

EU588842

to

EU588856

72526 (613)

R

EU588833

to

EU588841

J

89028 (824)

D

EU588763

to

EU588775

78569 (495)

R

EU588776

to

EU588785