The Mullins laboratory is located in the Rosen Building on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.

Lab News

New research featured in Science

"Cancer Genes Help HIV Persist, Complicating Cure Efforts."Science News & Analysis, 14 March 2014

RV144 Analysis Featured by Nature

"Vaccine trial reveals chinks in HIV's armour."Nature | News, 10 September 2012

Step Trial Analysis Featured in UW Today

"For first time, scientists show an HIV vaccine impacts the genetic makeup of the virus." UW Today, 1 March 2011


Recent Publications

Nedellec R, Herbeck J, Hunt PW, Deeks SG, Mullins JI, Anton ED, Reeves JD, Mosier DE 2016 High Sequence Diversity and Rapid Virus Turnover Contribute to Higher Rates of Coreceptor Switching in Treatment-Experienced Subjects with HIV-1 Viremia. AIDS research and human retroviruses Epub ahead of print pubmed

Smith KN, Mailliard RB, Piazza PA, Fischer W, Korber BT, Fecek RJ, Ratner D, Gupta P, Mullins JI, Rinaldo CR 2016 Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells. mBio73e00473-16 pubmed

Collier AC, Chun TW, Maenza J, Coombs RW, Tapia K, Chang M, Stevens CE, Justement JS, Murray D, Stekler JD, Mullins JI, Holte SE 2016 A Pilot Study of Raltegravir Plus Combination Antiretroviral Therapy in Early Human Immunodeficiency Virus Infection: Challenges and Lessons Learned. BioResearch open access5115-21 pubmed

McLaren PJ, Coulonges C, Bartha I, Lenz TL, Deutsch AJ, Bashirova A, Buchbinder S, Carrington MN, Cossarizza A, Dalmau J, De Luca A, Goedert JJ, Gurdasani D, Haas DW, Herbeck JT, Johnson EO, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, Poli G, Sandhu MS, Schuitemaker H, Shea PR, Theodorou I, Walker BD, Weintrob AC, Winkler CA, Wolinsky SM, Raychaudhuri S, Goldstein DB, Telenti A, de Bakker PI, Zagury JF, Fellay J 2015 Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. Proceedings of the National Academy of Sciences of the United States of America1124714658-63 pubmed

Peterson CW, Haworth KG, Polacino P, Huang ML, Sykes C, Obenza WM, Repetto AC, Kashuba A, Bumgarner R, DeRosa SC, Woolfrey AE, Jerome KR, Mullins JI, Hu SL, Kiem HP 2015 Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation. AIDS (London, England)29131597-606 pubmed

Department of Microbiology
School of Medicine
University of Washington
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