Mullins Molecular Retrovirology Lab
The Mullins laboratory is located in the Rosen Building on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.
New research featured in Science
RV144 Analysis Featured by Nature
Step Trial Analysis Featured in UW Today
High Sequence Diversity and Rapid Virus Turnover Contribute to Higher Rates of Coreceptor Switching in Treatment-Experienced Subjects with HIV-1 Viremia.
AIDS research and human retroviruses Epub ahead of print pubmed
Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells.
A Pilot Study of Raltegravir Plus Combination Antiretroviral Therapy in Early Human Immunodeficiency Virus Infection: Challenges and Lessons Learned.
BioResearch open access5115-21
Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
Proceedings of the National Academy of Sciences of the United States of America1124714658-63
Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation.
AIDS (London, England)29131597-606
Department of Microbiology
School of Medicine
University of Washington