Mullins Molecular Retrovirology Lab

  • Department of Microbiology
  • School of Medicine
  • University of Washington
University of Washington/Fred Hutch Center for AIDS Research

Mullins Lab

The Mullins laboratory is located in Building F on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.

Job Openings

Postdoctoral fellowship in chromatin structure analysis

We seek postdoctoral applicants with significant wet lab experience in molecular biology and interest in joining a multidisciplinary group studying the impact of HIV infection on nuclear structure, and in particular, epigenetic analysis of chromatin.

Postdoctoral fellowship in computational biology

We seek postdoctoral applicants with experience in computational analysis of protein structure to participate in multidisciplinary efforts focused on vaccine development by developing structure-based vaccine immunogen designs.

Recent Publications

Williams-Wietzikoski CA, Campbell MS, Payant R, Lam A, Zhao H, Huang H, Wald A, Stevens W, Gray G, Farquhar C, Rees H, Celum C, Mullins JI, Lingappa JR, Frenkel LM (2019). Comparisons of human immunodeficiency virus type 1 envelope variants in blood and genital fluids near the time of male-to-female transmission. Journal of virology (ePub ahead of print). (pubmed) (doi)

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Bull M, McKernan J, Styrchak S, Kraft K, Hitti J, Cohn SE, Tapia K, Deng W, Holte S, Mullins JI, Coombs RW, Frenkel L (2019). Phylogenetic analyses comparing HIV sequences from plasma at virologic failure to cervix vs. blood sequences from antecedent antiretroviral therapy suppression. AIDS research and human retroviruses (ePub ahead of print). (pubmed) (doi)

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Mackelprang RD, Bamshad MJ, Chong JX, Hou X, Buckingham KJ, Shively K, deBruyn G, Mugo NR, Mullins JI, McElrath MJ, Baeten JM, Celum C, Emond MJ, Lingappa JR, Partners in Prevention HSV/HIV Transmission Study and the Partners PrEP Study Teams (2019). Correction: Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1. PLoS pathogens, 15(2), e1007588. (pubmed) (doi)

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O'Connor MA, Munson PV, Tunggal HC, Hajari N, Lewis TB, Bratt D, Moats C, Smedley J, Bagley KC, Mullins JI, Fuller DH (2019). Mucosal T Helper 17 and T Regulatory Cell Homeostasis Correlate with Acute Simian Immunodeficiency Virus Viremia and Responsiveness to Antiretroviral Therapy in Macaques. AIDS research and human retroviruses, 35(3), 295-305. (pubmed) (doi)

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Hemelaar J, Elangovan R, Yun J, Dickson-Tetteh L, Fleminger I, Kirtley S, Williams B, Gouws-Williams E, Ghys PD, WHO–UNAIDS Network for HIV Isolation Characterisation (2019). Global and regional molecular epidemiology of HIV-1, 1990-2015: a systematic review, global survey, and trend analysis. The Lancet. Infectious diseases, 19(2), 143-155. (pubmed) (doi)

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