The Mullins laboratory is located in the Rosen Building on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.
RV144 Analysis Featured by Nature
Step Trial Analysis Featured in UW Today
2014 The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8(+) T cell responses. Virology450-45134-48 pubmed
2014 HIV-1 subtype C is not associated with higher risk of heterosexual HIV-1 transmission: a multinational study among HIV-1 serodiscordant couples. AIDS (London, England)282235-43 pubmed
2014 Variants in host viral replication cycle genes are associated with heterosexual HIV-1 acquisition in Africans. Journal of acquired immune deficiency syndromesEpub ahead of print pubmed
2014 Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques. PloS one91e86254 pubmed
2014 Toll-like Receptor Polymorphism Associations With HIV-1 Outcomes Among Sub-Saharan Africans. The Journal of infectious diseasesEpub ahead of print pubmed
