Mullins JI, Rolland M, Allen TM (2008). Viral evolution and escape during primary human immunodeficiency virus-1 infection: implications for vaccine design. Current opinion in HIV and AIDS, 3(1), 60-6. (pubmed) (doi)
The ability of human immunodeficiency virus to mutate rapidly to evade host immune pressures is a key hurdle limiting the control of human immunodeficiency virus-1 by cellular immune responses. Viral escape from CD8 T-cell recognition continues to be studied extensively, and emerging data provide greater appreciation of the affect of these mutations on the virus. These data may help identify key immune responses capable of suppressing viral replication. This goal remains critical, as current vaccines are unlikely to produce protective T-cell immunity.