Citation Information

Smith RA, Gottlieb GS, Miller AD (2010). Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors. Retrovirology, 7, 70. (pubmed) (doi)

Abstract

XMRV (xenotropic murine leukemia virus-related virus) is the first known example of an exogenous gammaretrovirus that can infect humans. A limited number of reports suggest that XMRV is intrinsically resistant to many of the antiretroviral drugs used to treat HIV-1 infection, but is sensitive to a small subset of these inhibitors. In the present study, we used a novel marker transfer assay to directly compare the antiviral drug sensitivities of XMRV and HIV-1 under identical conditions in the same host cell type.