Mullins Molecular Retrovirology Lab

  • Department of Microbiology
  • School of Medicine
  • University of Washington
University of Washington/Fred Hutch Center for AIDS Research

Citation Information

Ceresola ER, Nozza S, Sampaolo M, Pignataro AR, Saita D, Ferrarese R, Ripa M, Deng W, Mullins JI, Boeri E, Tambussi G, Toniolo A, Lazzarin A, Clementi M, Canducci F (2015). Performance of commonly used genotypic assays and comparison with phenotypic assays of HIV-1 coreceptor tropism in acutely HIV-1-infected patients. The Journal of antimicrobial chemotherapy, 70(5), 1391-5. (pubmed) (doi)

Abstract

Although founder viruses in primary HIV-1 infections (PHIs) typically use the CCR5 coreceptor (R5-tropic), 3%-19% of subjects also harbour CXCR4-using viruses (X4-tropic), making tropism determination before CCR5 antagonist usage mandatory. Genotypic methods can be used to accurately determine HIV-1 tropism in chronically infected patients.